The Hippo pathway has been delineated during the past four years (for recent reviews, see refs 3–5).Although primarily worked out in Drosophila, homologues of the pathway components exist in ...

It has long been understood that the Hippo pathway plays a critical role in the development of a wide range of diseases. Although once seen as an elusive pathway, emerging novel data and research ...

Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan ...

The researchers also looked at how PI5P4K activity influenced other components of the hippo pathway and found that reduced ...

The lab reported in the journal Science that a gene pathway called Hippo inhibits cardiac muscle regeneration during development. View the Science Journal article. Our lab is currently working to ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit flies and another important for the growth of embryos -- interact in embryonic mouse hearts to restrict cell ...

A phase 3 trial of lanifibranor, a pan-PPAR agonist, in patients with MASH and liver fibrosis is ongoing. But with the 96.6 ...