High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence. This lesion is characterized by ...

Other findings in the prostate might also indicate premalignant disorders, such as low-grade ... of focal atrophy with HGPIN has frequently been observed (Figure 6). [68] These atrophic lesions ...