High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence. This lesion is characterized by ...

Nat Clin Pract Urol. 2007;4(6):321-332. Blockade of 5α-reductase with drugs such as finasteride does not seem to induce large morphological changes in HGPIN, unlike other forms of androgen ...

Before it does so, patients may typically exhibit intraepithelial neoplasia, a potentially pre-cancerous change to the cervical cells. Cervical neoplasia is graded by how deeply the cell changes ...

Source Reference: Eerkens AL, et al "Vvax001, a therapeutic vaccine for patients with HPV16-positive high-grade cervical intraepithelial neoplasia: a phase II trial" Clin Cancer Res 2025 ...

More information: Vvax001, a therapeutic vaccine for patients with HPV16-positive high-grade cervical intraepithelial neoplasia: a Phase II trial, Clinical Cancer Research (2025). DOI: 10. ...

A therapeutic vaccine targeting human papillomavirus type 16 (HPV16) induced regression in high-grade precancerous ... In those with grade 3 cervical intraepithelial neoplasia (CIN3), cells ...

A therapeutic vaccine targeting human papillomavirus type 16 (HPV16) induced regression in high-grade precancerous ... In those with grade 3 cervical intraepithelial neoplasia (CIN3), cells ...

Get Instant Summarized Text (Gist) A therapeutic vaccine targeting HPV16 showed promise in reducing high-grade precancerous cervical lesions in a Phase II clinical trial. Among 18 patients with ...