Although ultrasound is operator dependent and usually detects steatosis only when more than 30% of hepatocytes are compromised by fat, 44 we found good agreement between ultrasound and biopsy ...

In both conditions the first manifestation of injury is the accumulation of fat within hepatocytes (steatosis), and in a proportion of patients this is followed by the development of ...

[54] NASH is presumed to develop as a consequence of a 'second' or 'multiple hits' on the steatotic hepatocytes. The first hit results from a number of pathways leading to hepatic steatosis.

Caption In response to alcohol, various cellular and molecular changes occur in the liver, contributing to hepatic steatosis, inflammation and fibrosis. Hepatocytes exhibit increased production of ...

More information: Yun Kwon et al, Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological ...