Once daily, 1 week AK lesion reduction from baseline: 28.8 Complete clearance: 0 AK lesion reduction from baseline: 62.6 Complete clearance: 18.1 <0.001 <0.001 In 5-FU group application, site ...

The severity of skin reactions to the treatment of actinic keratosis with 5-fluorouracil cream 4% was associated with a higher lesion clearance rate.

In clinical practice, the condition of these patients and the presence of AKs may warrant topical means ... RCT examining 0.5% 5-FU (Carac) once daily vs vehicle cream once daily for 7 days ...