The severity of skin reactions to the treatment of actinic keratosis with 5-fluorouracil cream 4% was associated with a higher lesion clearance rate.

In clinical practice, the condition of these patients and the presence of AKs may warrant topical means ... RCT examining 0.5% 5-FU (Carac) once daily vs vehicle cream once daily for 7 days ...

In conclusion, 0.5% 5-FU is significantly ... serious effects [25] 5.FU: 5-fluorouracil; AK: Actinic keratosis; DB: Double-blinded; FC: 5-fluorouracil cream; RCT: Randomized controlled trial ...