Although the pathogenesis of DKA is better understood than that of HHS, the basic underlying mechanism for both disorders is a reduction in the net effective concentration of circulating insulin ...

Diabetic ketoacidosis (DKA) is a dangerous buildup of acids called ketones in your blood. Ketones are produced when your body doesn’t have enough insulin to convert sugar into energy.

In the present proposed protocol, we have used essentially the same insulin regimen for both DKA and HHS, but because of a greater level of mental obtundation in HHS, we have recommended only ...