Cholestatic liver diseases (CLDs) are a group of disorders characterized by the impairment of bile formation, secretion, or excretion. This impairment leads to bile acid accumulation in the liver ...

The different mechanisms by which cholestatic and parenchymal liver disease can lead to reduced bone mass, the prevalence of osteopenia and osteoporosis in patients with early and advanced liver ...

Cholestatic liver diseases, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), are conditions characterized by impaired bile flow, leading to liver damage and ...

This study examined the natural history of infants born with alpha-1 antitrypsin (AAT) deficiency and liver disease ... by too few bile ducts resulting in cholestasis, can damage not only the ...

Announcing a new publication for Acta Materia Medica journal. Estrogens have been reported to cause dysfunction in biliary transport systems, thereby inducing cholestasis. Multidrug ...

In the case of abnormal liver function tests in the absence of additional symptoms, the drug should be continued only if it is being used to treat a serious disease (e.g. isoniazid for the ...

FIC1 disease collectively refers to a group of autosomal-recessive familial liver disorders characterized by intrahepatic cholestasis due to mutations in the ATP8B1 gene (initially named FIC1).

Cholestasis of pregnancy (also known as ... common in women carrying multiples and in women with a history of liver damage or disease. "This is my third pregnancy and I was told I was going ...

(Nasdaq: MIRM) today announced that on 10, 2025, the Compensation Committee of Mirum’s Board of Directors granted inducement ...