Another active area of research in the laboratory focuses on unraveling the mechanisms behind maladaptive, or pathological, and adaptive, or physiological, cardiac hypertrophy. In response to certain ...

Aim Differentiating physiological cardiac hypertrophy from pathology is challenging when the athlete presents with extreme anthropometry. While upper normal limits exist for maximal left ventricular ...

You have full access to this article via your institution. Though activation of the calcineurin pathway can produce cardiac hypertrophy in transgenic mice 3, the results of our study indicate that ...

Medically reviewed by Yasmine S. Ali, MD, MSCI Cardiomegaly is the term used to describe an enlarged heart. It is most ...

Cardiovascular system Cardiac hypertrophy; increased stroke volume (SV); decrease in resting heart rate (HR); increase in maximum cardiac output (Q); capillarisation at the lungs and muscles ...

Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Macrophages are important components of the internal immune cells, which profoundly affects the internal ...

Despite having cardiovascular risk factors, asymptomatic aircraft pilots referred for medical screenings demonstrate ...

Sirolimus, the active ingredient in Felycin-CA1, at a higher dose is used as an immunosuppressant in human patients receiving ...

Left ventricular hypertrophy (LVH) is an abnormal thickening of the left ventricular myocardium that occurs as an adaptive mechanism to increased afterload. The left ventricular myocytes ...

Research in our lab focuses on understanding how these calcium dynamics are regulated in normal and diseased hearts, and how abnormal intracellular calcium release may contribute to the development of ...