We developed computational methods to simulate and quantify blood-cell production, and these proved key to unlocking the insights in both papers. We were surprised to find that the lineage trees ...

Blood cell lineage diversity shrinks with age The researchers mapped the family trees of blood cells derived from each HSC.

Then they mapped single-cell lineage output to gene expression against a cDNA library to generate a molecular bridge database. Lu and her team used the database to quantify HSC lineage outputs across ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...